Thermo Fisher Scientific KIR2DS5 Polyclonal Antibody
Human KIR2DS5 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, Affinity chromatography로 정제됨. PBS/glycerol buffer에 보관되며 -20°C에서 안정적. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KIR2DS5 (Accession Q14953), corresponding to amino acid residues R170–V220 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853242 |
Product Specific Information
This antibody detects endogenous levels of total KIR2DS5.
Target Information
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous, located on chromosome 19q13.4 within the leukocyte receptor complex (LRC).
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain.
- Long cytoplasmic domain (L): Transduces inhibitory signals via immune tyrosine-based inhibitory motifs (ITIMs).
- Short cytoplasmic domain (S): Lacks ITIMs and associates with TYRO protein tyrosine kinase binding protein to transduce activating signals.
Ligands for several KIR proteins are subsets of HLA class I molecules, suggesting KIRs play an important role in immune regulation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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