Thermo Fisher Scientific KIR2DL5A Polyclonal Antibody
KIR2DL5A 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 사용 가능. Human 및 Rat 시료에 반응하며, Affinity chromatography로 정제됨. PBS buffer(50% glycerol 포함) 상태로 제공되며 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KIR2DL5A (Accession Q8N109), corresponding to amino acid residues S171–S221. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2853241 |
Product Specific Information
Antibody detects endogenous levels of total KIR2DL5A.
Target Information
KIR2DL5A and KIR2DL5B are Killer cell immunoglobulin-like receptors (KIRs), transmembrane glycoproteins expressed by natural killer cells and subsets of T cells.
The KIR genes are polymorphic and highly homologous, located in a cluster on chromosome 19q13.4 within the leukocyte receptor complex (LRC).
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by their cytoplasmic domain length (L or S).
Proteins with long cytoplasmic domains transduce inhibitory signals via ITIM motifs, while those with short domains associate with TYRO protein tyrosine kinase binding protein to transduce activating signals.
KIR2DL5A and KIR2DL5B act as receptors on NK cells for HLA-C alleles, preventing cell lysis by inhibiting NK cell activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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