Thermo Fisher Scientific MED11 Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000–1:3,000
• Immunocytochemistry (ICC/IF): 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total MED11.

Target Information

In mammalian cells, transcription is regulated in part by high molecular weight co-activating complexes that mediate signals between transcriptional activators and RNA polymerase II (Pol II). The mediator complex functions as a bridge between regulatory proteins and Pol II, thereby regulating Pol II-dependent transcription.

Med11 (mediator complex subunit 11) is a 117 amino acid nuclear protein and a component of the mediator complex. The gene encoding Med11 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes, p53 and BRCA1, are located on chromosome 17. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome, while BRCA1 is directly involved in DNA repair and is associated with predisposition to cancers of the ovary, colon, prostate gland, and fallopian tubes.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.