Thermo Fisher Scientific DLL4 Recombinant Rabbit Monoclonal Antibody (003)

Thermo Fisher Scientific DLL4 Recombinant Rabbit Monoclonal Antibody (Clone 003)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Additional Formats

• HRP Conjugate
• Request Custom Conjugation

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone the specific antibody DNA sequences from immunoreactive rabbits and screen individual clones for optimal performance.

Advantages include:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the rabbit immune repertoire

This antibody is specific for Human DLL4/Delta-4.

Target Information

Delta-like ligand 4 (DLL4), also known as Delta-4, is a transmembrane ligand for the Notch1 receptor. It is expressed in vascular tissues and plays a critical role in vascular development. DLL4 is induced by VEGF and acts as a negative feedback regulator of angiogenesis, promoting the formation of a mature vascular network.

DLL4 is strongly expressed in tumor vessels of clear-cell renal and bladder cancers. Inhibition of DLL4 leads to increased vascular proliferation but poor maturation, resulting in reduced tumor growth without apparent toxicity.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.