Thermo Fisher Scientific Interleukin-3 (IL-3) Monoclonal Antibody (IL3/4004)
인간 IL-3에 특이적인 마우스 단클론 항체로, 다양한 혈액세포 계열의 성장과 분화를 연구하는 데 사용. IHC(P), IHC(PFA), Peptide Array 등 다양한 응용 가능. 고순도 Protein A/G 정제, 액상 형태, 4°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL3/4004 |
| Immunogen | Recombinant fragment of human IL3 protein (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Interleukin 3 (IL-3), also called Mast Cell Growth Factor (MCGF), Multi-Colony Stimulating Factor (multi-CSF), or Eosinophil-CSF (E-CSF), is produced by activated T cells, mast cells, and eosinophils.
IL-3 is a hematopoietic growth factor that stimulates colony formation of erythroid, megakaryocyte, neutrophil, eosinophil, basophil, mast cell, and monocytic lineages.
Most of these functions are enhanced or dependent on co-stimulation with other cytokines.
Human and mouse IL-3 share only 29% sequence identity at the amino acid level, and the bioactivity of IL-3 is highly species-specific. For example, human IL-3 has no activity on mouse cells.
IL-3 is a potent growth-promoting cytokine capable of supporting the proliferation of a broad range of hematopoietic cell types, and is involved in cell growth, differentiation, and apoptosis.
It has also been shown to possess neurotrophic activity and may be associated with neurologic disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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