Thermo Fisher Scientific Interleukin-3 (IL-3) Monoclonal Antibody (IL3/4001)
인간 IL-3 단백질을 인식하는 Mouse monoclonal antibody로, 다양한 면역분석(IHC, Array, IE)에 적합합니다. 200 µg/mL 농도의 액상 형태이며, Protein A/G로 정제되었습니다. 인간 IL-3 관련 세포 성장 및 분화 연구에 활용됩니다.
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- 3562-MSM1-P1
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Thermo Fisher Scientific Interleukin-3 (IL-3) Monoclonal Antibody (IL3/4001)
Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL3/4001 |
| Immunogen | Recombinant fragment of human IL3 protein (amino acids 20–152) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Human thymus or tonsil tissue
- Cellular Localization: Secreted
Specificity Comments:
Interleukin-3 (IL-3) is a pleiotropic cytokine secreted by activated T lymphocytes that stimulates proliferation and differentiation of hematopoietic cells. It supports growth of pluripotent stem cells and differentiated progenitors, enhances activity of mature cells, and protects mast cells from apoptosis. IL-3 acts through a receptor involved in MAP kinase pathway activation. Upon stimulation, JAK2 phosphorylation occurs, leading to activation and nuclear translocation of Stat5a and Stat5b.
Target Information
Interleukin 3 (IL-3), also known as Mast Cell Growth Factor (MCGF), Multi-Colony Stimulating Factor (multi-CSF), or Eosinophil-CSF (E-CSF), is produced by activated T cells, mast cells, and eosinophils.
IL-3 is a hematopoietic growth factor that stimulates colony formation of erythroid, megakaryocyte, neutrophil, eosinophil, basophil, mast cell, and monocytic lineages. Many of these functions depend on co-stimulation with other cytokines.
Human and mouse IL-3 share only 29% amino acid sequence identity, and IL-3 activity is species-specific (human IL-3 is inactive on mouse cells).
IL-3 promotes proliferation and differentiation of hematopoietic cells and may also have neurotrophic activity related to neurological disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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