Thermo Fisher Scientific Human STIM2 Synthetic Peptide
Human STIM2 단백질의 C-말단 18개 아미노산 서열에 해당하는 합성 펩타이드로, PA5-20372 항체의 블로킹 펩타이드로 사용 가능. 인간 시료 반응성, 액상 형태, PBS 버퍼에 0.1% BSA 및 0.02% sodium azide 포함. 연구용으로만 사용.
- 카탈로그번호
- PEP0489
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human STIM2 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the carboxy terminus of human STIM2.
PEP-0489 can be used as a blocking peptide with polyclonal antibody PA5-20372.
Target Information
In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are composed of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), which acts as a Ca++ sensor and activates CRAC channels by migrating to the plasma membrane from ER-like sites that serve as Ca++ stores.
A related molecule, STIM2, inhibits STIM1-mediated store-operated Ca++ entry and can form complexes with STIM1, suggesting a coordinated role in regulating Ca++ entry. At least three isoforms of STIM2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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