Thermo Fisher Scientific Human Presenilin 1 Synthetic Peptide
인간 Presenilin 1의 C-말단 23개 아미노산 서열에 해당하는 합성 펩타이드. PA5-20376 항체의 블로킹 펩타이드로 사용 가능. 알츠하이머병 연구 등에서 감마-시크리타제 복합체 관련 단백질 분석에 활용. 연구용 전용 시약.
- 판매단위
- pk
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 23 amino acids near the carboxy terminus of human presenilin 1.
PEP-0493 can be used as a blocking peptide with polyclonal antibody PA5-20376.
Target Information
Presenilin 1 was initially identified as a marker of susceptibility to early-onset Alzheimer’s disease.
Along with PEN2, nicastrin, and APH-1, Presenilin 1 forms the γ-secretase protein complex, a membrane-bound aspartyl protease that cleaves certain proteins within the hydrophobic environment of the lipid bilayer.
This cleavage is crucial for signaling from several cell-surface receptors and is required for generating neurotoxic amyloid peptides central to Alzheimer’s disease pathogenesis.
Similar to TACE and BACE protease families, γ-secretase cleaves the amyloid precursor protein (APP) within its intramembrane region, producing either the non-toxic p3 peptide or the toxic Aβ amyloid peptide.
Accumulation of Aβ peptide is thought to precede Alzheimer’s disease. Multiple isoforms of presenilin 1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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