Thermo Fisher Scientific CDH3 Monoclonal Antibody (OTI2D5), TrueMAB
CDH3 단백질을 인식하는 Mouse IgG2a 형 단일클론 항체로, Western Blot, IHC, ICC/IF에 사용 가능. HEK293T에서 발현된 full-length human CDH3 항원으로 제작. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:4,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D5 |
| Immunogen | Full length human recombinant protein of human CDH3 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
P-cadherin (Cadherin-3, CDH3) is a Type 1 cadherin protein belonging to the cadherin superfamily.
It is a single-pass transmembrane glycoprotein with five extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin.
Cadherins mediate calcium-dependent cell-cell adhesion and are involved in development, wound healing, cell signaling, growth, and differentiation.
P-cadherin is expressed in human fetal tissues and adult organs including epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium.
It is also found in embryonic stem cells and mammary gland stem cells.
Overexpression of P-cadherin is correlated with poor prognosis in several carcinomas (breast, prostate, ovary, colon, stomach).
Mutations in CDH3 are linked to congenital hypotrichosis with juvenile macular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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