Thermo Fisher Scientific IDO1 Monoclonal Antibody (OTI1A3), TrueMAB
IDO1 단백질을 특이적으로 인식하는 Mouse Monoclonal Antibody로, IDO2와 교차 반응하지 않음. Western Blot, IHC, ICC 등 다양한 응용에 적합. 고순도 Affinity Chromatography 정제 및 안정적 PBS/BSA/glycerol 저장 버퍼 구성. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A3 |
| Immunogen | Full length human recombinant protein of human IDO1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
This antibody is specific to IDO1 without cross-reacting with IDO2.
Target Information
IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules such as tryptophan, serotonin, and melatonin. Through this process, IDO1 initiates the production of biologically active metabolites known as kynurenines.
IDO1 is widely expressed in human tissues, macrophages, and dendritic cells (DCs). During inflammation, interferons (IFNs) trigger IDO1 induction, contributing to antimicrobial mechanisms. Degradation of tryptophan by IDO1 inhibits the growth of viruses, bacteria, and parasites.
Additionally, IDO1 plays a crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: TA506402_IDO_P14902-1_House_mouse.svg, TA506402_IDO_P14902-1_House_mouse_PDP.jpeg)
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