Thermo Fisher Scientific TRIM56 Polyclonal Antibody
Human TRIM56 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol) 버퍼에 저장됩니다. E3 유비퀴틴-프로테인 리가아제 연구 및 항바이러스 면역 기전 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TRIM56. Recombinant protein control fragment (Product #RP-92861) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648933 |
Product Specific Information
Immunogen sequence:
PECRETVPVP PEGVASFKTN FFVNGLLDLV KARACGDLRA GKPACALCPL VGGTSTGGPA TARCLDCADD LCQACADGHR C
Highest antigen sequence identity to the following orthologs:
- Mouse: 88%
- Rat: 29%
Target Information
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118).
In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to Lys-63-linked ubiquitination, promoting its homodimerization required for type I interferon (IFN-beta) production.
Independently of its E3 ligase activity, acts as a positive regulator of TLR3 signaling. Enhances extracellular dsRNA-induced expression of IFNB1 and interferon-stimulated genes (ISG15, IFIT1/ISG56, CXCL10, OASL, CCL5/RANTES).
Promotes antiviral state and TLR3-mediated chemokine induction following hepatitis C virus infection (PubMed:22948160). [UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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