Thermo Fisher Scientific Cerebellin 2 Polyclonal Antibody
Thermo Fisher Scientific의 Cerebellin 2 Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western blot 및 Immunocytochemistry에 적합합니다. Rabbit polyclonal 항체로, CBLN2의 내인성 수준을 검출하며 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CBLN2 (Accession Q8IUK8), corresponding to amino acid residues M1–R50 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850949 |
Product Specific Information
Antibody detects endogenous levels of total CBLN2.
Target Information
Cerebellin (CER), originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1 (Cbln1). Four propeptides—Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3), and Cerebellin 4 (Cbln4)—form the precerebellin subfamily within the C1q protein family. These proteins act as transneuronal regulators of synapse development and plasticity in various brain regions.
Cerebellin and its metabolite des-Ser(1)Cer are also expressed in extra-cerebellar tissues such as the adrenal gland. Cerebellin 1, 2, and 3 can form both homomeric and heteromeric complexes, influencing each other’s degradation and secretion. Cerebellin 3 cannot form homomeric complexes and is secreted only when forming a heteromeric complex with Cerebellin 1. Decreased Cerebellin levels have been observed in patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role in disease pathology.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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