Thermo Fisher Scientific CBLN4 Polyclonal Antibody
CBLN4 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 -20°C 보관.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CBLN4 (Accession Q9NTU7), corresponding to amino acid residues V25–A75 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850950 |
Product Specific Information
Antibody detects endogenous levels of total CBLN4.
Target Information
Cerebellin (CER), originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1 (precerebellin 1 or Cbln1). Four propeptides—Cerebellin 1, 2 (Cbln2), 3 (Cbln3), and 4 (Cbln4)—form the precerebellin subfamily within the C1q protein family.
Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. Cerebellin and its metabolite, des-Ser(1)Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland.
Cerebellin 1, 2, and 3 assemble into homomeric and heteromeric complexes, influencing each other’s degradation and secretion. Cerebellin 3 can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting its role in disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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