Thermo Fisher Scientific Phospho-ER (Ser118) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive control: MCF-7
• Cellular location: Nucleus

Target Information

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, induces a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins.

There are two forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2). Due to alternative RNA splicing, at least four estrogen receptor-alpha isoforms are known: Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), and Isoform 4 (35 kDa). Estrogen receptors are widely expressed in various tissues and are essential for sexual development and reproductive function, as well as roles in bone and other tissues. They are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.