Thermo Fisher Scientific Phospho-ER (Ser118) Polyclonal Antibody
인체 ERα Ser118 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제된 액상 형태. MCF-7 세포 양성 대조로 사용 가능. 핵 내 ER 검출에 적합.
- 카탈로그번호
- 600-300ABBOMAX
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-ER (Ser118) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide surrounding the epitope -QL-S-PF- with a phosphorylation site of Ser118 of human estrogen receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: MCF-7
- Cellular location: Nucleus
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, induces a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins.
There are two forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2). Due to alternative RNA splicing, at least four estrogen receptor-alpha isoforms are known: Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), and Isoform 4 (35 kDa). Estrogen receptors are widely expressed in various tissues and are essential for sexual development and reproductive function, as well as roles in bone and other tissues. They are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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