Thermo Fisher Scientific Insulin Receptor Alpha Recombinant Rabbit Monoclonal Antibody (INSR, 2277R)
Thermo Fisher의 재조합 토끼 단클론 항체로 인간 Insulin Receptor Alpha를 특이적으로 인식합니다. IHC(P) 검증 완료, 고순도 Protein A/G 정제. PBS(pH 7.4) 용액 형태로 제공되며 방부제 무첨가. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- 3643-RBM2-P1ABX
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Insulin Receptor Alpha Recombinant Rabbit Monoclonal Antibody (INSR, 2277R)
Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | INSR, 2277R |
| Immunogen | Recombinant fragment of extracellular domain of human Insulin Receptor alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For Immunohistochemistry (PFA fixed):
Incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of phosphorylation cascades.
Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins.
These receptors differ in sequence regions that confer ligand specificity and in intracellular signaling domains, resulting in distinct functional outcomes.
Defects in the insulin receptor (IR) are associated with insulin resistance syndromes, while IGF-1R defects may cause certain types of growth retardation.
Both signaling cascades are also important in cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.