Thermo Fisher Scientific SNAI2 Monoclonal Antibody (OTI4B3), TrueMAB

Applications

• Western Blot (WB): 1:1,000 dilution tested

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step (e.g., using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Slug (SNAI2) is a member of the Snail family of C2H2-type zinc finger transcription factors. It plays a key role in epithelial-mesenchymal transition (EMT) and neural tube formation during vertebrate embryogenesis.
Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug binds to E-box promoter regions and represses transcription of genes like E-cadherin and Claudin-1.
Its expression in breast, esophageal, and colorectal carcinomas has been correlated with poor prognosis. Additionally, Slug can protect hematopoietic progenitor cells from radiation-induced apoptosis by repressing p53-mediated transcription of Puma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.