Thermo Fisher Scientific MLH1 Recombinant Rabbit Monoclonal Antibody (8K1T2)
Recombinant rabbit monoclonal antibody targeting MLH1 for IHC (paraffin) applications. Reacts with human and mouse. Validated clone 8K1T2 with high specificity. Supplied as liquid, affinity purified, and stored in PBS with glycerol. For research use only.
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Applications
- Immunohistochemistry (Paraffin) (IHC-P): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8K1T2 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 350–450 of human MLH1 (NP_000240.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.69 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2849490 |
Product Specific Information
Immunogen sequence:
PGLAGPSGEM VKSTTSLTSS STSGSSDKVY AHQMVRTDSR EQKLDAFLQP LSKPLSSQPQ AIVTEDKTDI SSGRARQQDE EMLELPAPAE VAAKNQSLEG D
Target Information
MLH1 is a DNA mismatch repair protein essential for maintaining genetic stability. Defects in this pathway can lead to microsatellite instability (MSI), associated with various cancers including hereditary nonpolyposis colon cancer (HNPCC). MLH1 forms a heterodimer with PMSH after MSH2 recognizes mismatched nucleotides, facilitating subsequent repair steps.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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