Thermo Fisher Scientific SKP1 Polyclonal Antibody
SKP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P)에서 사용 가능. 인간 및 생쥐 반응성, 고순도 항원 친화 크로마토그래피 정제. 장기 보관 시 -20°C에서 안정적이며 연구용으로 적합.
- 카탈로그번호
- PA528489
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–163 of Human SKP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545965 |
Product Specific Information
- Recommended positive controls: A549, H1299, HCT116, MCF-7, NIH-3T3
- Predicted reactivity: Rat (100%), Zebrafish (99%), Xenopus laevis (100%), Dog (100%), Chicken (100%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%), Guinea pig (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a component of SCF complexes, which include SKP1, cullin 1, a ring-box protein, and one member of the F-box family. SKP1 binds directly to the F-box motif found in F-box proteins. SCF complexes regulate ubiquitination of specific substrates, targeting them for proteasomal degradation. F-box proteins recognize different targets, and many SCF substrates have been identified, including regulators of cell cycle progression and development. SKP1 has also been characterized as an RNA polymerase II elongation factor. Alternative splicing produces two transcript variants, and a related pseudogene exists on chromosome 7.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm. For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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