Thermo Fisher Scientific LIMD1 Polyclonal Antibody
LIMD1 단백질을 인식하는 Thermo Fisher의 토끼 폴리클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간 및 마우스 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체이며, 4°C 또는 -20°C에서 보관. 연구용 전용 제품.
- 카탈로그번호
- PA528491
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 472–676 of Human LIMD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545967 |
Product Specific Information
- Recommended positive controls: 293T, mouse brain
- Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (81%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The Zyxin family of proteins contains five members: Ajuba, Limd1, LPP, TRIP6, and Zyxin.
Limd1 (LIM domain-containing protein 1) is a ubiquitously expressed tumor suppressor containing three LIM zinc-binding domains. LIM domains consist of a cysteine-rich consensus sequence containing two distinct zinc-binding subdomains, which mediate protein-protein interactions.
Limd1 interacts with SQSTM1, Rb, p62, and TRAF6. It was first identified when the deletion of its gene was noted in some cervical cancers. Limd1 blocks in vitro and in vivo tumor growth and is downregulated in lung cancer.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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