Thermo Fisher Scientific Phospho-Tau protein (Ser531) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, suggesting Tau functions as a linker protein between both. Axonal polarity is determined by TAU/MAPT localization within the neuronal cell body.

Short isoforms allow cytoskeletal plasticity, while longer isoforms contribute to stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary tangles in Alzheimer’s disease (AD). Hyper-phosphorylation disrupts Tau’s microtubule-binding ability, leading to neuronal degeneration. Tau phosphorylation is regulated by kinases such as GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also associated with other neurodegenerative disorders, including Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.