Thermo Fisher Scientific Phospho-Tau protein (Thr529) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Tau is a neuronal microtubule-associated protein predominantly found on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both. Axonal polarity is determined by TAU/MAPT localization in the cell body domain defined by the centrosome.

Short isoforms provide cytoskeletal plasticity, whereas longer isoforms contribute to stabilization. Hyper-phosphorylated Tau forms paired helical filaments (PHF), the main component of neurofibrillary lesions in Alzheimer’s disease (AD) brains. This modification impairs microtubule binding, leading to destabilization and neuronal degeneration. Tau phosphorylation is regulated by kinases such as GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is associated with neurofibrillary lesions in Alzheimer’s disease, Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.