Thermo Fisher Scientific Renal Cell Carcinoma (Carbonic Anhydrase IX) Monoclonal Antibody (CA9/3405)
신장암 관련 표지자인 Carbonic Anhydrase IX(CA IX)를 인식하는 단클론 항체로, 인체 시료에 반응. IHC, Flow Cytometry 등 다양한 응용 가능. 단백질 A/G로 정제된 액상형 비결합 항체. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CA9/3405 |
| Immunogen | Recombinant human CA9 protein fragment (around aa 314–410) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Carbonic anhydrase (CA) is an enzyme that assists the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues.
CA IX is one of the most inducible genes under hypoxic conditions via HIF-1 alpha, due to its stability and membrane localization.
Carbonic anhydrases regulate pH in normal tissues by controlling hydrogen ion (H⁺) flux. Blockade of CA IX increases cell death under hypoxia, making CA IX a reliable histochemical marker of hypoxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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