Thermo Fisher Scientific PDI Monoclonal Antibody (38H8)

Applications

Western Blot (WB)

• Tested Dilution: 1:10,000
• View 1 publication

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:500–1:1,000
• View publication

Product Specifications

Product Specific Information

MA1-10032 detects PDI1P from S. cerevisiae samples.

Target Information

Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage, and rearrangement of disulfide bonds.
At the cell surface, PDI acts as a reductase that cleaves disulfide bonds of proteins attached to the cell, potentially causing structural modifications of exofacial proteins.
Inside the cell, PDI forms or rearranges disulfide bonds of nascent proteins.
At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins; at low concentrations, it facilitates aggregation (anti-chaperone activity).
PDI may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis.
It also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein (MTTP).
Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state, and enhancing cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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