Thermo Fisher Scientific WTAP Monoclonal Antibody (OTI6H3), TrueMAB
Human, Mouse, Rat에 반응하는 WTAP 단일클론 항체로 Western blot과 IHC(Paraffin)에 적합. Lyophilized 형태로 제공되며 PBS buffer에 trehalose 포함. 고순도 Affinity chromatography 정제, 연구용으로 WTAP 단백질 검출에 활용.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6H3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 2–106 of human WTAP produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended product: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Wilms' tumor (WT) is an embryonal kidney malignancy affecting 1 in 10,000 infants, found in both sporadic and inherited forms.
WT1 binds the DNA sequence GCGGGGGCG and functions as a transcriptional repressor.
WTAP (Wilms tumor 1-associating protein) is a nuclear protein interacting with WT1, involved in mRNA splicing regulation.
WTAP localizes to nuclear speckles and regulates the G2/M cell cycle transition by stabilizing cyclin A2 mRNA.
It inhibits expression of WT1 target genes and reduces WT1 DNA-binding ability.
Two isoforms of WTAP exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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