Thermo Fisher Scientific WTAP Monoclonal Antibody (OTI2C4), TrueMAB
WTAP 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western blot에 적합. 인간, 생쥐, 랫트 반응성. 동결건조 형태로 제공되며 PBS 버퍼에 8% 트레할로스 포함. 연구용으로 mRNA 스플라이싱 및 세포주기 조절 연구에 활용 가능.
- 판매단위
- pk
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 2–106 of human WTAP produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Wilms' tumor (WT) is an embryonal kidney malignancy affecting 1 in 10,000 infants. The Wilms' tumor protein (WT1) binds DNA at the GCGGGGGCG sequence, acting as a transcriptional repressor. WTAP (Wilms tumor 1-associating protein) is a nuclear protein interacting with WT1, involved in mRNA splicing regulation.
WTAP localizes in nuclear speckles and regulates the G2/M cell cycle transition by binding to the 3′ UTR of cyclin A2, enhancing its stability. It also inhibits WT1 target gene expression and interferes with WT1 DNA binding. Two isoforms of WTAP exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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