Thermo Fisher Scientific JAKMIP1 Polyclonal Antibody
JAKMIP1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간 및 마우스 시료에서 반응하며, PBS/glycerol 용액에 보관됩니다. Affinity chromatography로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JAKMIP1 (Accession Q96N16), corresponding to amino acid residues K434–A484 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2815803 |
Product Specific Information
Antibody detects endogenous levels of total JAKMIP1.
Target Information
JAKMIP1 (also known as Marlin-1) is a vertebrate-specific microtubule-associated protein involved in JAK1 signaling and regulation of microtubule cytoskeleton rearrangements. It is predominantly expressed in neuronal and lymphoid cells and colocalizes with microtubules.
Multiple isoforms exist:
- Isoforms 1 and 5 are expressed in liver, lung, and skeletal muscle.
- Isoforms 2–4 are specifically expressed in brain and retina.
JAKMIP1 participates in polarized secretion in lymphocytes and may function as a novel effector memory gene restraining T cell-mediated cytotoxicity. Dysregulation of JAKMIP1 expression has been linked to genetic conditions associated with autism in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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