Thermo Fisher Scientific Cathepsin A Polyclonal Antibody
Cathepsin A 단백질을 검출하기 위한 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 IHC(P) 실험에 적합하며, 고순도의 Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CTSA (Accession P10619), corresponding to amino acid residues L394–F444. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852184 |
Product Specific Information
Antibody detects endogenous levels of total CTSA.
Target Information
The cathepsin family of proteolytic enzymes includes several diverse classes of proteases. Cathepsins B, L, H, K, S, and O comprise the cysteine protease class, while cathepsins D and E are aspartyl proteases. The serine protease class includes cathepsin G.
Cathepsins play roles in cellular metabolism, peptide biosynthesis, and protein degradation.
Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with β-galactosidase (β-gal) and α-neuraminidase (Neu1), functioning to protect these enzymes from intralysosomal proteolysis.
Deficiencies in cathepsin A lead to deficiencies in β-gal and Neu1, and mutations in the human cathepsin A gene (chromosome 20q13.12) cause galactosialidosis, a lysosomal storage disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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