Thermo Fisher Scientific UBE2C Polyclonal Antibody
UBE2C 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot 및 IHC(파라핀 포함)에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 고순도의 Affinity chromatography 정제 항체입니다. -20°C 보관, 연구용 전용입니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human UBE2C (Accession O00762), corresponding to amino acid residues P147–P179. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852182 |
Product Specific Information
Antibody detects endogenous levels of total UBE2C.
Target Information
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression.
It accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
In vitro, it catalyzes Lys-11- and Lys-48-linked polyubiquitination.
Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis.
Acts by initiating Lys-11-linked polyubiquitin chains on APC/C substrates, leading to their degradation by the proteasome and promoting mitotic exit.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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