Thermo Fisher Scientific PKP2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total PKP2.

Target Information

Plakophilins 1, 2, 3, and 4 (PKP1–4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments.
These proteins contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes—junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress.

• Plakophilin 1: Mediates increases in desmosomal protein content, desmosome assembly, and regulation of cell migration.
• Plakophilin 2: Essential for desmosome assembly and acts as a morphogenic factor and architectural component of the heart.
• Plakophilin 4: Regulates junctional plaque organization and cadherin function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.