Thermo Fisher Scientific PKP2 Polyclonal Antibody
PKP2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 적합. 인간, 생쥐, 랫트에서 반응하며, 고순도 친화 크로마토그래피 정제. 액상 형태로 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PKP2 (Accession Q99959), corresponding to amino acid residues P105–S155 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2852186 |
Product Specific Information
Antibody detects endogenous levels of total PKP2.
Target Information
Plakophilins 1, 2, 3, and 4 (PKP1–4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments.
These proteins contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes—junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress.
- Plakophilin 1: Mediates increases in desmosomal protein content, desmosome assembly, and regulation of cell migration.
- Plakophilin 2: Essential for desmosome assembly and acts as a morphogenic factor and architectural component of the heart.
- Plakophilin 4: Regulates junctional plaque organization and cadherin function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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