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ELK Biotechnology Keap-1 rabbit pAb
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ELK Biotechnology Keap-1 rabbit pAb

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Keap-1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간, 생쥐, 랫트 시료에서 반응하며, 세포질 및 핵에 주로 위치한 KEAP1 단백질 검출에 유용합니다. -20°C에서 1년 보관 가능합니다.

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ELK Biotechnology ES3948-100UL Keap-1 rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES3948-50UL Keap-1 rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology Keap-1 rabbit pAb

Keap-1 rabbit pAb

제품 정보

항목 내용
Product name Keap-1 rabbit pAb
Alternative Names KEAP1; INRF2; KIAA0132; KLHL19; Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; INrf2; Kelch-like protein 19
Applications WB; IHC; IF; ELISA
Recommended Dilutions Western Blot: 1/500 - 1/2000
IHC-p: 1/100 - 1/300
ELISA: 1/20000
Not yet tested in other applications
Immunogen The antiserum was produced against synthesized peptide derived from the internal region of human KEAP1. AA range: 411–460
Host Rabbit
Storage -20°C / 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 70 kDa
Gene ID (Human) 9817
Human Swiss-Prot No. Q14145
Cellular Localization Cytoplasm, Nucleus. Mainly cytoplasmic (PubMed:15601839). In response to selective autophagy, relocalizes to inclusion bodies following interaction with SQSTM1/p62 (PubMed:20452972).
Species Reactivity Human; Mouse; Rat

Background

This gene encodes a protein containing KELCH-like domains and a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 (Nrf2) in a redox-sensitive manner. The dissociation of these proteins in the cytoplasm allows Nrf2 to translocate to the nucleus, leading to the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been identified for this gene (RefSeq, Jul 2008).

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