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ELK Biotechnology Vasohibin rabbit pAb
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인간 VASH1 유래 펩타이드로 제작된 Vasohibin 토끼 폴리클로날 항체. WB 및 ELISA에 적합하며, 세포질 및 분비 단백질 검출에 활용. 혈관신생 억제 관련 연구에 유용. -20°C에서 1년 보관 가능.
- 카탈로그번호
- ES3685-xxxxx (2개 옵션)
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ELK Biotechnology ES3685-100UL Vasohibin rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES3685-50UL Vasohibin rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Vasohibin rabbit pAb
Vasohibin rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Vasohibin rabbit pAb |
| Alternative Names | VASH1; KIAA1036; VASH; Vasohibin-1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human VASH1 (AA range: 261–310) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 40 kDa |
| GeneID (Human) | 22846 |
| Human Swiss-Prot No | Q7L8A9 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm and secreted. Mainly localizes in cytoplasm (PubMed:27879017). Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:27879017). |
Background
- Function: Angiogenesis inhibitor that suppresses migration, proliferation, and network formation by endothelial cells. Inhibits tumor growth and angiogenesis without affecting smooth muscle cells, fibroblasts, or cancer cell proliferation in vitro.
- Mechanism: Acts in an autocrine manner; inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.
- Induction: By VEGF.
- Post-Translational Modifications (PTM): Exists as multiple processed forms (42, 36, 32, 27 kDa). The 42 kDa form is secreted, while the 36 kDa form accumulates intracellularly.
- Similarity: Belongs to the vasohibin family.
- Tissue Specificity: Preferentially expressed in endothelial cells; highly expressed in fetal organs, brain, and placenta; lower expression in heart and kidney; strongly detected in microvascular endothelial cells of atherosclerotic lesions.
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