ELK Biotechnology MCM3 rabbit pAb
MCM3 단백질에 특이적인 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 쥐, 랫트 시료에 반응. 핵 내 염색체 관련 복제 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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제품명
MCM3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MCM3; DNA replication licensing factor MCM3; DNA polymerase alpha holoenzyme-associated protein P1; P1-MCM3; RLF subunit beta; p102 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human MCM3 (AA range: 641–690) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 89 kDa |
| Gene ID (Human) | 4172 |
| Human Swiss-Prot No. | P25205 |
| Cellular Localization | Nucleus; Chromosome; Associated with chromatin before the formation of nuclei and detaches as DNA replication progresses |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) involved in the initiation of eukaryotic genome replication. The hexameric complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may participate in replication fork formation and recruitment of other DNA replication-related proteins.
This protein is a subunit of the MCM2–7 complex and interacts directly with MCM5/CDC46. It also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. Acetylation inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been identified for this gene. (RefSeq, Jul 2012)
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