ELK Biotechnology Glypican-3 rabbit pAb
Glypican-3 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 세포막 GPI-앵커 단백질 검출에 적합하며, 세포 성장 조절 관련 연구에 유용.
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Glypican-3 rabbit pAb
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| 항목 | 내용 |
|---|---|
| Product name | Glypican-3 rabbit pAb |
| Alternative Names | GPC3; OCI5; Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from the internal region of human GPC3 (AA range: 461–510) |
| Storage | -20°C, 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 70 kDa |
| Gene ID (Human) | 2719 |
| Human Swiss-Prot No. | P51654 |
| Cellular Localization | Cell membrane; Lipid-anchor (GPI-anchor); Extracellular side |
| Species Reactivity | Human; Mouse; Rat |
Background
Cell surface heparan sulfate proteoglycans consist of a membrane-associated protein core with heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) are anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play roles in cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26 and induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome (Simpson dysmorphia syndrome). Alternative splicing results in multiple transcript variants. [RefSeq, Sep 2009]
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