ELK Biotechnology cPLA2 rabbit pAb
Human, Mouse, Rat에 반응하는 cPLA2 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 적합합니다. N-terminal region (AA 31-80)에서 유래한 면역원 사용. 세포질, 골지체, 핵막에 위치하며 염증 반응 관련 연구에 활용됩니다.
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제품명
cPLA2 rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PLA2G4A; CPLA2; PLA2G4; Cytosolic phospholipase A2; cPLA2; Phospholipase A2 group IVA |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from the N-terminal region of human PLA2G4A (AA range: 31–80) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 114 kDa |
| Gene ID (Human) | 5321 |
| Human Swiss-Prot No | P47712 |
| Cellular Localization | Cytoplasm, Golgi apparatus membrane, Nuclear envelope. Translocates to intracellular membranes in a calcium-dependent manner. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid, which is subsequently metabolized into eicosanoids.
Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways.
The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor.
The enzyme is activated by increased intracellular Ca²⁺ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Alternative splicing results in multiple transcript variants. (RefSeq, Jul 2015)
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