ELK Biotechnology IL-10 rabbit pAb
IL-10 rabbit pAb는 인간, 마우스, 랫트에서 반응하는 폴리클로날 항체로 면역조절 및 염증 연구에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며 고순도 IgG 형태로 제공됩니다. 합성 펩타이드 기반으로 제작되어 높은 특이성과 재현성을 제공합니다.
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제품명
IL-10 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| 공급업체 | ELK Biotechnology |
| Alternative Names | IL10; Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 IF: 1/100–1/300 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from the internal region of human IL10 (AA range: 71–120) |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 20 kD |
| GeneID (Human) | 3586 |
| Human Swiss-Prot No | P22301 |
| Cellular Localization | Secreted |
| Storage | -20°C / 1 year |
| Host | Rabbit |
배경 정보
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested its essential role as an immunoregulator in the intestinal tract. Mutations in this gene are associated with increased susceptibility to HIV-1 infection and rheumatoid arthritis. (RefSeq, May 2011)
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