ELK Biotechnology PAOX rabbit pAb

제품명

PAOX rabbit pAb

제품 개요

PAOX(Peroxisomal N(1)-acetyl-spermine/spermidine oxidase)는 폴리아민 대사에 관여하는 FAD 의존성 효소로, 세포 내 폴리아민 농도 조절에 중요한 역할을 합니다. 본 항체는 PAOX 단백질을 특이적으로 인식하는 토끼 유래 폴리클로날 항체입니다.

제품 사양

Background

• Catalytic activity:
  • N(1),N(12)-diacetylspermine + O₂ + H₂O → N(1)-acetylspermidine + 3-acetamidobutanal + H₂O₂
  • N(1)-acetylspermidine + O₂ + H₂O → putrescine + 3-acetamidopropanal + H₂O₂
  • N(1)-acetylspermine + O₂ + H₂O → spermidine + 3-acetamidopropanal + H₂O₂
• Cofactor: Binds 1 FAD per subunit
• Function: Flavoenzyme catalyzing oxidation of N(1)-acetylspermine to spermidine; involved in polyamine back-conversion. Also oxidizes N(1)-acetylspermidine to putrescine.
• Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine.
• Biological role: Regulates intracellular polyamine concentration; may determine cellular sensitivity to antitumor polyamine analogs.
• Induction: By polyamine analogs.
• Miscellaneous: Oxidizes N(1)-acetylated polyamines on the exo-side of their N(4)-amino groups.
• Pathway: Amine and polyamine metabolism; spermine metabolism.
• Similarity: Belongs to the flavin monoamine oxidase family.
• Subunit: Monomer.
• Tissue specificity: Widely expressed; not detected in spleen; lower expression in neoplastic tissues.