ELK Biotechnology UHRF1 rabbit pAb
UHRF1 단백질을 인식하는 rabbit polyclonal antibody로, Western blot과 ELISA에 적합합니다. 인간, 생쥐, 랫트 시료에서 반응하며 핵 내 UHRF1 단백질 검출에 사용됩니다. 1 mg/ml 농도, -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology UHRF1 rabbit pAb
제품명
UHRF1 rabbit pAb
공급업체
ELK Biotechnology
제품 개요
UHRF1 단백질을 인식하는 rabbit polyclonal antibody입니다. Western blot 및 ELISA 실험에 사용되며, 핵 내 UHRF1 단백질의 위치 및 발현 연구에 적합합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | UHRF1; ICBP90; NP95; RNF106; E3 ubiquitin-protein ligase UHRF1; Inverted CCAAT box-binding protein of 90 kDa; Nuclear protein 95; Nuclear zinc finger protein Np95; HuNp95; hNp95; RING finger protein 106; Transcription factor ICBP90; Ubiquitin-like PHD and RING finger domain-containing protein 1; hUHRF1; Ubiquitin-like-containing PHD and RING finger domains protein 1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000; ELISA: 1/40000; Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human UHRF1 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 89 kD |
| Gene ID (Human) | 29128 |
| Human Swiss-Prot No | Q96T88 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Nucleus; Localizes to replication foci; Enriched in pericentric heterochromatin; Also localizes to euchromatic regions |
Background
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIα and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. (RefSeq, Feb 2014)
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.