ELK Biotechnology XPLN rabbit pAb
XPLN rabbit pAb는 인간, 마우스, 랫에서 반응하는 다클론 항체로 ARHGEF3 단백질을 인식합니다. WB, IHC, IF, ELISA에 적합하며, 세포질에 위치한 Rho GTPase 관련 단백질 연구에 유용합니다. 장기 보관은 -20°C에서 가능합니다.
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제품명
XPLN rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | XPLN rabbit pAb |
| Alternative Names | ARHGEF3; Rho guanine nucleotide exchange factor 3; Exchange factor found in platelets and leukemic and neuronal tissues; XPLN |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000; IHC-p: 1/50–300; ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen | Synthesized peptide derived from human ARHGEF3 (AA range: 456–505) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kD |
| GeneID (Human) | 50650 |
| Human Swiss-Prot No | Q9NR81 |
| Cellular Localization | Cytoplasm |
| Species Reactivity | Human; Mouse; Rat |
Background
Rho-like GTPases are involved in various cellular processes and are activated by GTP binding and inactivated by GTP hydrolysis. Guanine nucleotide exchange factors (GEFs) facilitate activation by promoting GDP release. The ARHGEF3 gene encodes a GEF that specifically activates RHOA and RHOB, both associated with bone cell biology. Genetic variations in ARHGEF3 influence bone mineral density (BMD), suggesting a role in postmenopausal osteoporosis. Multiple alternatively spliced transcript variants encode different isoforms of this gene. (RefSeq, Jul 2008)
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