ELK Biotechnology XPG rabbit pAb
ERCC5(XPG) 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫트 시료에 반응하며, 핵 내 DNA 손상 복구 관련 단백질 검출에 적합. -20°C 보관, 1 mg/ml 농도.
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제품명
XPG rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ERCC5; ERCM2; XPG; XPGC; DNA repair protein complementing XP-G cells; DNA excision repair protein ERCC-5; Xeroderma pigmentosum group G-complementing protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human ERCC5 (AA range: 131–180) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 130 kDa |
| Gene ID (Human) | 2073 |
| Human Swiss-Prot No. | P28715 |
| Cellular Localization | Nucleus, Chromosome. Colocalizes with RAD51 to nuclear foci in S phase (PubMed:26833090). Localizes to DNA double-strand breaks during replication stress (PubMed:26833090). Colocalizes with BRCA2 to nuclear foci following DNA replication stress (PubMed:26833090). |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a single-strand specific DNA endonuclease that makes the 3′ incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription and transcription-coupled DNA repair.
Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), also known as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and an increased risk of skin cancer. Some patients also develop Cockayne syndrome, which involves severe growth defects, mental retardation, and cachexia.
Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [RefSeq, Feb 2011]
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