ELK Biotechnology WASP rabbit pAb
WASP rabbit pAb는 인간 및 마우스 시료에 반응하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간 WASP 유래 펩타이드로 면역화되었으며, 세포질 및 핵에 위치한 단백질 검출에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
WASP rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | WAS; IMD2; Wiskott-Aldrich syndrome protein; WASp |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human WASP (AA range: 256–305) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| Gene ID (Human) | 7454 |
| Human Swiss-Prot No. | P42768 |
| Cellular Localization | Cytoplasm, cytoskeleton, nucleus |
| Species Reactivity | Human, Mouse |
Background
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structures and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. These proteins are regulated by multiple stimuli and interact with various proteins. Studies have shown that they associate with the small GTPase Cdc42, which regulates actin filament formation, and the cytoskeletal organizing complex Arp2/3.
Wiskott-Aldrich syndrome is a rare, inherited, X-linked recessive disease characterized by immune dysregulation and microthrombocytopenia, caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein expressed exclusively in hematopoietic cells, showing signaling and cytoskeletal abnormalities in WAS patients.
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