ELK Biotechnology VDR rabbit pAb
Vitamin D3 receptor(VDR)을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간, 생쥐, 랫트에 반응하며 핵과 세포질에 주로 위치합니다. 농도 1 mg/ml, -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology VDR rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | VDR rabbit pAb |
| Alternative Names | VDR; NR1I1; Vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Vitamin D Receptor (AA range: 181–230) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38 kDa |
| Gene ID (Human) | 7421 |
| Human Swiss-Prot No. | P11473 |
| Cellular Localization | Nucleus, Cytoplasm. Localizes mainly to the nucleus (PubMed:28698609, PubMed:12145331). Localization to the nucleus is enhanced by vitamin D3. |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes the nuclear hormone receptor for vitamin D3. It also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to steroid and thyroid hormone receptors. Downstream targets are mainly involved in mineral metabolism, but it also regulates immune response and cancer-related pathways. Mutations are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing produces multiple transcript variants encoding different proteins.
(Provided by RefSeq, Feb 2011)
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