ELK Biotechnology Vav1 rabbit pAb

제품명

Vav1 rabbit pAb

제품 설명

Vav1 단백질을 인식하는 토끼 다클론 항체입니다. Rho family GTPases의 구아닌 뉴클레오타이드 교환 인자로 작용하는 VAV 단백질을 검출할 수 있으며, 세포골격 재배열 및 전사 조절 연구에 활용됩니다. 또한 T세포 및 B세포의 발달과 활성화에 중요한 역할을 하는 단백질로, HIV-1 Nef 단백질과의 상호작용 연구에도 사용됩니다.

제품 사양

Background

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements, and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]