Thermo Fisher Scientific Cycloxygenase-2 (COX-2) Monoclonal Antibody (COX2, 1941)
Cyclooxygenase-2(COX-2)에 특이적인 Mouse monoclonal 항체로, Western blot 등 연구용에 적합합니다. 인간 시료에 반응하며, Recombinant COX2 단백질(aa 442-572)을 면역원으로 제작되었습니다. Protein A/G 정제, PBS buffer, 보존제 무첨가, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | COX2, 1941 |
| Immunogen | Recombinant human COX2 protein fragment (around aa 442–572) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
This antibody is tested in direct ELISA.
Use antibody at 2–4 µg/mL for coating.
Target Information
COX2 converts arachidonate to prostaglandin H2 (PGH2), a key step in prostanoid synthesis including inflammatory prostaglandins. The conversion involves two reactions:
- Cyclooxygenase (COX) reaction — converts arachidonate to prostaglandin G2 (PGG2)
- Peroxidase reaction — reduces PGG2 to prostaglandin H2 (PGH2)
COX2 is constitutively expressed in some tissues such as endothelium, kidney, and brain, and is upregulated under pathological conditions like cancer and inflammation. Unlike PTGS1, which is ubiquitously expressed, COX2 upregulation is associated with increased cell adhesion, phenotypic changes, apoptosis resistance, and tumor angiogenesis.
In cancer cells, COX2 facilitates production of prostaglandin E2 (PGE2), influencing motility, proliferation, and apoptosis resistance. COX2 is naturally inhibited by calcitriol (active Vitamin D) and suppressed by glucocorticoids through transcriptional repression. It is a pharmacological target of NSAIDs such as aspirin, which reduce pain and inflammation mediated by COX2 activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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