Thermo Fisher Scientific Cycloxygenase-2 (COX-2) Monoclonal Antibody (COX2/2377)
COX-2 단일클론 항체로 인간 시료에 반응하며 IHC(P) 및 IHC(PFA)에서 사용 가능. Recombinant COX2 단백질을 면역원으로 제작된 Mouse IgG2a 항체. 단백질 A/G로 정제된 액상 형태로, PBS buffer 내 보존. 연구용으로만 사용.
- 카탈로그번호
- 5743-MSM2-P1ABX
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | COX2/2377 |
| Immunogen | Recombinant human COX2 protein fragment (around aa 442–572) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including production of inflammatory prostaglandins.
The conversion of arachidonate to prostaglandin H2 is a two-step reaction:
- A cyclooxygenase (COX) reaction converting arachidonate to prostaglandin G2 (PGG2).
- A peroxidase reaction reducing PGG2 to prostaglandin H2 (PGH2).
COX2 is constitutively expressed in certain tissues such as endothelium, kidney, and brain, and is up-regulated under pathological conditions like cancer and inflammation.
It is associated with increased cell adhesion, phenotypic changes, resistance to apoptosis, and tumor angiogenesis.
In cancer cells, COX2 is critical for prostaglandin E2 (PGE2) production, influencing motility, proliferation, and apoptosis resistance.
COX2 activity is naturally inhibited by calcitriol (active Vitamin D) and repressed by glucocorticoids.
COX2 is a known target of NSAIDs such as aspirin, which reduce pain and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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