Thermo Fisher Scientific PAPPA2 Polyclonal Antibody
Human PAPPA2 단백질을 인식하는 Goat Polyclonal Antibody로 Western blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS 및 trehalose 버퍼에 동결건조 형태로 제공. 연구용으로만 사용 가능.
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- PA547179
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카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunoprecipitation (IP) | 25 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human Pappalysin-2/PAPP-A2 (Ser234–Cys1396) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2605662 |
Product Specific Information
- In Western blots, less than 1% cross-reactivity with recombinant human PAPP-A is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in an IGF-independent fashion.
It is suggested that cleavage of IGFBP-5 and, to a lesser extent, IGFBP-3 produced in the maternal decidua promotes feto-placental growth.
Elevated PLAC3 levels have been observed in hypertensive disorders of pregnancy, including preeclampsia and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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