Thermo Fisher Scientific MCG10 Polyclonal Antibody
Rabbit polyclonal antibody against human MCG10, suitable for IHC, ICC, and ELISA applications. Recognizes MCG10 involved in RNA-binding and tumor suppression. Supplied as liquid, purified by Protein A, stored at -20°C for research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human MCG10 (amino acids 1–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MCG10 is a member of the KH-domain RNA-binding protein family, also known as alpha-CPs, which bind to RNA with specificity for C-rich pyrimidine regions. These proteins play key roles in post-transcriptional regulation and exhibit diverse cellular distributions. MCG10 is induced by p53 and DNA damage through two p53-responsive promoter elements. Overexpression leads to suppression of cell proliferation via apoptosis and G2-M cell cycle arrest. Decreased expression of certain MCG10 isoforms has been observed in various lung cancers, suggesting a tumor suppressor role. Multiple alternatively spliced isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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