Thermo Fisher Scientific p19ARF Polyclonal Antibody
p19ARF 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 종 특이성은 Mouse와 Rat이며, Protein A로 정제된 액상 항체입니다. 종양 억제 관련 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from Rat P19ARF, amino acids 101–160 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action differ.
p19ARF functions as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals.
Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors, indicating that p19ARF is an important tumor suppressor.
Additionally, p19ARF helps prevent transforming signals from various oncoproteins via the p53 regulatory loop, highlighting its crucial role in cell cycle control and tumor suppression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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