Thermo Fisher Scientific GABABR1 Polyclonal Antibody
GABABR1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC, Flow Cytometry 및 ELISA에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도의 액상 제품. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human GABABR1 (amino acids 651–750) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium channels, and modulate inositol phospholipid hydrolysis. Plays a critical role in fine-tuning inhibitory synaptic transmission.
Presynaptic GABA-B receptors inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B receptors decrease neuronal excitability by activating inwardly rectifying potassium (Kir) conductance.
Involved in synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation, and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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