Thermo Fisher Scientific TMEM119 Polyclonal Antibody
TMEM119 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 및 마우스 시료에 반응합니다. Western blot, ICC/IF, Flow cytometry에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 미세아교세포 표지 연구에 활용 가능합니다.
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- PA5119902
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:5,000 | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 | – |
| Flow Cytometry (Flow) | 1:100–1:500 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human TMEM119 (aa 11–52/283) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913474 |
Product Specific Information
- Positive Control: Mouse brain tissue lysate, mouse cerebellum tissue lysate, SH-SY5Y
- Subcellular Location: Endoplasmic reticulum membrane, Cell membrane, Cytoplasm
Target Information
Tmem119 encodes a single-pass type I transmembrane protein that interacts with various micro-RNAs and transcription factors such as SMAD1, SMAD5, and RUNX2. TMEM119 serves as a surface marker of microglia, distinguishing them from infiltrating macrophages. Microglia are brain-resident phagocytes involved in debris clearance and neuronal dendrite pruning, exhibiting neuroprotective and neurotoxic roles depending on environmental cues.
Reactive microglia co-express Iba1 and, when stimulated with LPS, secrete Cq1, IL-1α, and TNF, potentially contributing to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and multiple sclerosis. TMEM119’s precise role in microglial function remains under investigation. Outside the neural system, TMEM119 may play a role in osteoblast differentiation and ossification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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