Thermo Fisher Scientific HAS1 Monoclonal Antibody (5B5B4)
Thermo Fisher Scientific의 HAS1 단클론 항체(5B5B4)는 인간 HAS1 단백질을 인식하며, Western blot, IHC, ICC/IF, Flow cytometry, ELISA 등 다양한 응용에 적합합니다. 단백질 G로 정제된 액상형 항체로, 1 mg/mL 농도를 가지며 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5B5B4 |
| Immunogen | Purified recombinant fragment of human HAS1 (AA 74–399) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090812 |
Target Information
Hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide that forms part of the extracellular matrix in organisms ranging from bacteria to mammals. It consists of alternating glucuronic acid and N-acetylglucosamine residues linked by β-1,3 and β-1,4 glycosidic bonds. HA is synthesized at the plasma membrane by membrane-bound synthase and extruded into the extracellular space, serving roles in space filling, joint lubrication, and as a migration matrix for cells.
HA production increases during wound healing and tissue repair, supporting blood vessel and fibroblast ingrowth. Serum HA concentration changes are linked to inflammatory and degenerative conditions such as rheumatoid arthritis. The interaction between HA and the leukocyte receptor CD44 is critical for leukocyte homing, and overexpression of HA receptors correlates with tumor metastasis.
HAS1 is a member of the vertebrate gene family encoding hyaluronan synthases, showing significant homology to the hasA gene product of Streptococcus pyogenes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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